Jack Humphrey, PhD
Principal Investigator 

Jack obtained his Ph.D. in Clinical Neuroscience from University College London in 2019, after spending time as a visiting researcher at Stanford University and as a computational scientist at Inivata Ltd, a Cambridge, UK-based biotech startup. He joined the lab of Towfique Raj at Mount Sinai as a postdoctoral fellow in 2019, and was promoted to Instructor in 2021. In 2025 he was promoted to Assistant Professor. He is also a Visiting Scientist at the New York Genome Center.  In his spare time he goes rock climbing and plays the bass. Read his CV.

Alice Maria Giani, PhD
Postdoctoral Fellow

Alice is a physicist by training who transitioned to study Neuroscience in her Master’s studies at the University of Milano-Bicocca . During her PhD at the University of Milan and Yale University she investigated the molecular mechanisms underpinning neurodevelopmental disorders using induced pluripotent stem cells (iPSCs) and functional genomics. She joined Dr. Shuibing Chen's lab at Weill Cornell Medicine to develop a barcoded human iPSC library and investigate the risk loci associated with Zika virus and other viral infections in neurons. She then joined Dr. Li Gan’s lab at Weill Cornell Medicine to investigate modifiers of tau aggregation and propagation.  She is currently exploring the role of aberrant mRNA splicing in ALS, FTD, and AD using single-cell approaches.

Brooke Friedman
PhD student  (co-mentored with Prof Towfique Raj)

Brooke is a neuroscience Ph.D. student at Mount Sinai who is originally from Santa Clarita, California. She graduated magna cum laude from the University of Notre Dame in May 2024, where she studied neuroscience, linguistics, and global engagement.  She is exploring the role of TDP-43 in Alzheimer's disease and Frontotemporal dementia. In her free time, she enjoys doing aerial silks and running through Central Park.

Faith Singh
Master's Student

Faith graduated from Hunter College with a Bachelors’ degree in biological sciences with a concentration of neurobiology. Her previous experience was as a clinical research coordinator at Lenox Hill Hospital Department of Neurosurgery. She graduated from her Master’s in Biomedical Sciences at Mount Sinai in June 2025. She is exploring  shared and specific gene expression changes in ALS postmortem tissues using multi-omic integration.

Alexander Chung
MD/PhD student (co-mentored with Prof Towfique Raj)

Alexander is an MD/PhD student who graduated from Cornell University. For his senior honors thesis, he researched the role of olfactory sensory neuron-derived extracellular vesicles in peripheral nerve regeneration in the lab of Dr. David Lin. After graduation, he worked in the lab of Dr. Mark Albers at Massachusetts General Hospital where he studied type I interferon neuroinflammation in the context of Alzheimer's Disease and ALS. He is currently interested in studying the genetics of immune cells in neurodegenerative diseases.

Ali Oku
Bioinformatics Analyst, New York Genome Center

Ali Oku is a bioinformatics analyst with a Master's in Bioinformatics and Computer Science. He currently works at the New York Genome Center specializing in analyzing bulk and single-cell RNA-seq datasets across a diverse range of diseases.  He works with Jack on analyzing the New York Genome Center ALS Consortium cohort.

Judy Liang
Volunteer

Judy completed her Master's in Computer Science at the University of Pennsylvania while working with Jack on ALS and FTD postmortem tissue transcriptomics. She is now pursuing a project with Mosaic Neuroscience to subtype ALS patients using multi-omic profiles from iPS-derived motor neurons.

Dr Irika Sinha
Assistant Scientist, now at Allen Institute

Rahat Hasan
Master's Student, now at Bristol Myers Squibb

Flora (Hyomin) Seo
Master's Student, now at Mount Sinai Center for Advanced Genomics Technology

Dr Winston Dredge (formerly Cuddleston)
PhD Student, now Postdoc at University of Washington

Towfique Raj
Departments of Neuroscience, Genetics and Genomic Sciences
Mount Sinai School of Medicine

Kurt Farrell
John Crary
Department of Pathology
Mount Sinai School of Medicine

Hemali Phatnani
David Knowles
New York Genome Center
Columbia University

Philip Hasel
University of Edinburgh

Rickie Patani
National University of Singapore

Pietro Fratta
Matthew Keuss
Tammaryn Lashley
Ariana Gatt
Andrea Malaspina
Queen Square Institute of Neurology
University College London